Differex™ System

The Power of Differential Extraction

The Differex™ System offers recovery similar to that of the standard method commonly used for differential extraction. The Differex™ System works with challenging new and old samples typical of those from sexual assaults. The Differex™ System is used in combination with the DNA IQ™ System and Slicprep™ 96 Device on robotic platforms to process up to 48 differential extractions in less than 5 hours, including incubation time, and less than 1 hour of hands-on time. The Differex™ System is the first and only system that allows a forensic laboratory to automate every step of differential extraction. Direct compatibility with the DNA IQ™ System and downstream STR applications allows you to be confident in your ability to obtain results regardless of your choice of STR systems.

Promega forensic products are manufactured in alignment with the ISO 18385 standard.This standard ensures minimal risk of human DNA contamination for products used to collect, store and analyze biological materials for forensic purposes. Learn more.

The Power of Automation

Sexual assault samples provide valuable forensic information. However, mixture samples are among the most difficult to process, as sperm and epithelial fractions first must be separated. The automated Differex™ System provides an alternative to cumbersome manual methods by automating differential extraction. Robotic processing of mixture samples can reduce case backlogs without compromising quality. The automated Differex™ System combines Differex™ reagents with proven DNA IQ™ chemistry and specialized methods for complete and clean differential extraction.

The Power of Speed

It can take up to 5 days to process 40 differential extraction samples using the typical manual differential extraction method, and the final results may be variable, depending on the analyst's skill level. With the automated Differex™ method you can process up to 40 differential extraction samples, from incubation to final eluted DNA, in less than 5 hours. Hands-on time is less than 1 hour, reducing total processing time by up to 90%.

Want to Automate?

Save time by automating the Differex™ System on the Biomek® 3000 and 4000 (Beckman Coulter) Laboratory Automation Workstations. Further streamline your sexual assault sample processing by integrating Differex with the DNA IQ™ System.

Automate your Differential Extraction

Contact your local representative to receive a quote for the required quantities and to purchase and schedule the required installation and training services.

Consumables

Product	Size	Cat.#
2.2ml, Square-Well Deep Well Plate	50/pack	V6781
Proteinase K	100mg	V3021
DTT, Molecular Grade (Dry Powder)	25g	V3155
Lysis Buffer	150ml	A8261
SlicPrep™ 96 Device	10/pack	V1391
Nuclease-Free Water	50ml	P1193
Nuclease-Free Water	150ml	P1195

Hardware

Product	Cat.#
MagnaBot® 96 Magnetic Separation Device	V8151

Protocols

Complete Protocol

Differex™ System Technical ManualPDF (1272 KB) – English

Video Protocols

What's in the box?

Item	Part #	Size	Available Separately
Digestion Buffer	A850A	1 × 25ml	View Product
Separation Solution	A851A	1 × 5ml	View Product
Nuclease-Free Water	P119H	2 × 25ml	View Product

SDS

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Certificate of Analysis

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Use Restrictions

Not For Medical Diagnostic Use.

Storage Conditions

Patents and Disclaimers

U.S. Pat. No. 7,320,891.