SH2B3, SH2B adaptor protein 3

SH2B3, SH2B adaptor protein 3

• This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

• Gene Synonyms (SH2B adapter protein 3, lymphocyte-specific adapter protein Lnk, signal transduction protein Lnk, truncated SH2B3, IDDM20, LNK,)
• NCBI Gene ID: 10019
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UQQ2
  UNIPROT ID#>>F5GYM4
  UNIPROT ID#>>Q96BA5
  UNIPROT ID#>>Q59H48
  UNIPROT ID#>>B7Z7K6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SH2B adaptor protein 3 interacts with:

• abraxas 2, BRISC complex subunit
  SH2B adaptor protein 3
  tensin 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.