- Gene Overview
- Interaction Network
- Sequence Verification
ABCC5, ATP binding cassette subfamily C member 5
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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Gene Synonyms (multidrug resistance-associated protein 5, ATP-binding cassette, sub-family C (CFTR/MRP), member 5, canalicular multispecific organic anion transporter C, multi-specific organic anion transporter C, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11,)
- NCBI Gene ID:
10057
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>O15440
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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ATP binding cassette subfamily C member 5 interacts with:
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