OPTN, optineurin

OPTN, optineurin

• This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

• Gene Synonyms (optineurin, E3-14.7K-interacting protein, FIP-2, HIP-7, Huntingtin interacting protein L, huntingtin yeast partner L, huntingtin-interacting protein 7, huntingtin-interacting protein L, nemo-related protein, optic neuropathy-inducing protein, transcription factor IIIA-interacting protein, transcrption factor IIIA-interacting protein, tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains, ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP,)
• NCBI Gene ID: 10133
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96CV9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

optineurin interacts with:

• arrestin domain containing 3
  autophagy related 16 like 1
  autophagy related 5
  baculoviral IAP repeat containing 6
  coiled-coil domain containing 13
  eukaryotic translation initiation factor 5A2
  GABA type A receptor associated protein like 1
  GABA type A receptor associated protein like 2
  GABA type A receptor-associated protein
  heat shock transcription factor 2 binding protein
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  ligand of numb-protein X 2
  membrane palmitoylated protein 6
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein 1 light chain 3 beta
  microtubule associated protein 1 light chain 3 gamma
  optineurin
  potassium channel tetramerization domain containing 17
  POU class 6 homeobox 2
  protein inhibitor of activated STAT 4
  RAB10, member RAS oncogene family
  RAB12, member RAS oncogene family
  RAB14, member RAS oncogene family
  RAB25, member RAS oncogene family
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 11
  ring finger protein 216
  RNA binding motif protein 12
  SMC5-SMC6 complex localization factor 2
  SUB1 regulator of transcription
  syntaxin 12
  TANK binding kinase 1
  TANK-binding kinase 1
  TBC1 domain family member 15
  TBC1 domain family member 17
  TNFAIP3 interacting protein 1
  trafficking protein particle complex 5
  tripartite motif containing 16
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquinol-cytochrome c reductase complex III subunit VII
  WASH complex subunit 3
  WD repeat domain 20
  WD repeat domain, phosphoinositide interacting 2
  WD repeat domain, phosphoinositide interacting 2
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 329
  zinc finger protein 384
  zinc finger protein 398
  zinc finger protein 426
  zinc finger protein 670

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.