PMVK, phosphomevalonate kinase

PMVK, phosphomevalonate kinase

• This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

• Gene Synonyms (HUMPMKI, PMK, PMKA, PMKASE, POROK1, phosphomevalonate kinase, testis tissue sperm-binding protein Li 95mP,)
• NCBI Gene ID: 10654
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6FGV9
  UNIPROT ID#>>Q15126
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

phosphomevalonate kinase interacts with:

• ADP ribosylation factor like GTPase 6 interacting protein 6
  centromere protein H
  DNA damage inducible transcript 4 like
  fibronectin type III and SPRY domain containing 1
  forty-two-three domain containing 1
  methyl-CpG binding domain protein 5
  microcephalin 1
  NKD inhibitor of WNT signaling pathway 2
  odontogenesis associated phosphoprotein
  phosphomevalonate kinase
  retinol dehydrogenase 12
  SET domain containing 3, actin histidine methyltransferase
  small nuclear ribonucleoprotein U4/U6.U5 subunit 27
  sodium channel modifier 1
  solute carrier family 25 member 32
  solute carrier family 25 member 35
  WD repeat domain 92
  ZNF559-ZNF177 readthrough

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.