ALDH1L1, aldehyde dehydrogenase 1 family member L1

ALDH1L1, aldehyde dehydrogenase 1 family member L1

• The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

• Gene Synonyms (10-FTHFDH, 10-fTHF, FDH, FTHFD, cytosolic 10-formyltetrahydrofolate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, MER57B-ALDH1L1,)
• NCBI Gene ID: 10840
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q53H87
  UNIPROT ID#>>O75891
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

aldehyde dehydrogenase 1 family member L1 interacts with:

• aldehyde dehydrogenase 1 family member L2
  clusterin associated protein 1
  coiled-coil domain containing 88C
  ubiquilin 2
  ubiquitin specific peptidase 47

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.