HCST, hematopoietic cell signal transducer

HCST, hematopoietic cell signal transducer

• This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (DAP10, KAP10, PIK3AP, hematopoietic cell signal transducer, DNAX-activation protein 10, kinase assoc pro of ~10kDa, kinase assoc protein, membrane protein DAP10, phosphoinositide-3-kinase adaptor protein, transmembrane adapter protein KAP10,)
• NCBI Gene ID: 10870
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBK5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hematopoietic cell signal transducer interacts with:

• killer cell lectin like receptor K1
  SEC22 homolog A, vesicle trafficking protein
  STARD3 N-terminal like
  V-set and transmembrane domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.