ME3, malic enzyme 3

ME3, malic enzyme 3

• Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (NADP-ME, NADP-dependent malic enzyme, mitochondrial, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), malic enzyme 3, NADP(+)-dependent, mitochondrial, malic enzyme, NADP+-dependent, mitochondrial, mitochondrial NADP(+)-dependent malic enzyme 3, pyruvic-malic carboxylase,)
• NCBI Gene ID: 10873
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2R995
  UNIPROT ID#>>Q6TCH8
  UNIPROT ID#>>Q16798
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

malic enzyme 3 interacts with:

• ras homolog family member U

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.