IL24, interleukin 24

IL24, interleukin 24

• This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C49A, FISP, IL10B, MDA7, MOB5, ST16, interleukin-24, IL-4-induced secreted protein, melanocyte-associated Mda-7, melanoma differentiation-associated gene 7 protein, suppression of tumorigenicity 16 (melanoma differentiation),)
• NCBI Gene ID: 11009
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13007
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 24 interacts with:

• checkpoint kinase 2
  dermcidin
  early endosome antigen 1
  F-box and WD repeat domain containing 7
  interleukin 20 receptor subunit alpha
  partner and localizer of BRCA2
  Rac GTPase-activating protein 1
  receptor interacting serine/threonine kinase 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.