SLAMF6, SLAM family member 6

SLAMF6, SLAM family member 6

• The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

• Gene Synonyms (CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, SLAM family member 6, NK-T-B-antigen, NTBA receptor, activating NK receptor, natural killer-, T- and B-cell antigen,)
• NCBI Gene ID: 114836
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4E1U5
  UNIPROT ID#>>Q96DU3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SLAM family member 6 interacts with:

• BRICHOS domain containing 5
  claudin 19
  SLAM family member 6
  transmembrane protein with metallophosphoesterase domain

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.