ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

• The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

• Gene Synonyms (CENTD1, PARX, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, Arf and Rho GAP adapter protein 2, centaurin-delta-1,)
• NCBI Gene ID: 116984
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WZ64
  UNIPROT ID#>>A7E2A5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 interacts with:

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.