LRRK2, leucine rich repeat kinase 2

LRRK2, leucine rich repeat kinase 2

• This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

• Gene Synonyms (AURA17, DARDARIN, PARK8, RIPK7, ROCO2, leucine-rich repeat serine/threonine-protein kinase 2, augmented in rheumatoid arthritis 17,)
• NCBI Gene ID: 120892
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5S007
  UNIPROT ID#>>Q17RV3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich repeat kinase 2 interacts with:

• actin beta like 2
  ankyrin repeat and sterile alpha motif domain containing 4B
  chromosome 1 open reading frame 87
  chromosome 18 open reading frame 25
  coiled-coil domain containing 43
  CUE domain containing 1
  DnaJ heat shock protein family (Hsp40) member B8
  enkurin, TRPC channel interacting protein
  family with sequence similarity 47 member B
  gametocyte specific factor 1
  leucine rich repeat kinase 2
  NME1-NME2 readthrough
  potassium channel tetramerization domain containing 18
  RALY RNA binding protein like
  ribosomal biogenesis factor
  smoothelin like 2
  spindle and kinetochore associated complex subunit 3
  taste 2 receptor member 60
  t-complex 10 like
  tubulin beta class I
  tubulin, beta 4B class IVB
  UBX domain protein 10
  xin actin binding repeat containing 2
  YTH N6-methyladenosine RNA binding protein 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.