- Gene Overview
- Interaction Network
- Sequence Verification
PSMB11, proteasome subunit beta 11
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Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).[supplied by OMIM, Mar 2008]
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Gene Synonyms (BETA5T, proteasome subunit beta type-11, proteasome (prosome, macropain) subunit, beta type, 11, proteasome subunit beta 5T, proteasome subunit beta-5t,)
- NCBI Gene ID:
122706
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>A5LHX3
UNIPROT ID#>>B3KVC3
- View the NCBI Database
for this Gene »
Gene products are often involved in multiple pathways and networks within a living
cell. Learn more about other interacting partners.
proteasome subunit beta 11 interacts with:
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