LRR1, leucine rich repeat protein 1

LRR1, leucine rich repeat protein 1

• The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

• Gene Synonyms (4-1BBLRR, LRR-1, PPIL5, leucine-rich repeat protein 1, 4-1BB-mediated signaling molecule, LRR-repeat protein 1, cyclophilin-like 5, epididymis secretory sperm binding protein, peptidylprolyl isomerase (cyclophilin)-like 5, peptidylprolyl isomerase-like 5,)
• NCBI Gene ID: 122769
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96L50
  UNIPROT ID#>>Q6AWA7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leucine rich repeat protein 1 interacts with:

• RELT like 2
  zinc finger and BTB domain containing 38

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.