RNF217, ring finger protein 217

RNF217, ring finger protein 217

• This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

• Gene Synonyms (probable E3 ubiquitin-protein ligase RNF217, IBR domain containing 1, opposite STL, C6orf172, IBRDC1, OSTL, dJ84N20.1,)
• NCBI Gene ID: 154214
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TC41
  UNIPROT ID#>>B3KVC8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 217 interacts with:

• actin beta like 2
  H1.7 linker histone

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.