SLC30A8, solute carrier family 30 member 8

SLC30A8, solute carrier family 30 member 8

• The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

• Gene Synonyms (zinc transporter 8, solute carrier family 30 (zinc transporter), member 8, zinc transporter ZnT-8, ZNT8, ZnT-8,)
• NCBI Gene ID: 169026
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IWU4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 30 member 8 interacts with:

• complexin 4
  endogenous retrovirus group FRD member 1, envelope
  family with sequence similarity 209 member A
  leucine twenty homeobox
  RELT like 2
  SFT2 domain containing 2
  transmembrane protein 31
  transmembrane protein 80
  transmembrane protein 9
  Yip1 domain family member 6

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.