CERS3, ceramide synthase 3

CERS3, ceramide synthase 3

• This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

• Gene Synonyms (ceramide synthase 3, LAG1 homolog, ceramide synthase 3, LAG1 longevity assurance homolog 3, dihydroceramide synthase 3, sphingosine N-acyltransferase CERS3, ARCI9, LASS3,)
• NCBI Gene ID: 204219
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IU89
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ceramide synthase 3 interacts with:

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