NFASC, neurofascin

NFASC, neurofascin

• This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]

• Gene Synonyms (NEDCPMD, NF, NRCAML, neurofascin, neurofascin homolog, neurofascin isoform 140,)
• NCBI Gene ID: 23114
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94856
  UNIPROT ID#>>B4DRH7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neurofascin interacts with:

• neurofascin
  ring finger protein 123
  sodium voltage-gated channel beta subunit 3
  syndecan binding protein 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.