KANK1, KN motif and ankyrin repeat domains 1

KANK1, KN motif and ankyrin repeat domains 1

• The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]

• Gene Synonyms (ANKRD15, CPSQ2, KANK, KN motif and ankyrin repeat domain-containing protein 1, ankyrin repeat domain-containing protein 15, kidney ankyrin repeat-containing protein,)
• NCBI Gene ID: 23189
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14678
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

KN motif and ankyrin repeat domains 1 interacts with:

• dynein light chain LC8-type 1
  kinesin family member 21A
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.