HEY2, hes related family bHLH transcription factor with YRPW motif 2

HEY2, hes related family bHLH transcription factor with YRPW motif 2

• This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (hairy/enhancer-of-split related with YRPW motif protein 2, HES-related repressor protein 1, HES-related repressor protein 2, HESR-2, HRT-2, cardiovascular basic helix-loop-helix factor 1, cardiovascular helix-loop-helix factor 1, class B basic helix-loop-helix protein 32, hCHF1, hHRT2, hairy and enhancer of split-related protein 2, hairy-related transcription factor 2, hairy/enhancer-of-split related with YRPW motif 2, protein gridlock homolog, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32,)
• NCBI Gene ID: 23493
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q5TF93
  UNIPROT ID#>>Q9UBP5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hes related family bHLH transcription factor with YRPW motif 2 interacts with:

• ADP ribosylation factor like GTPase 10
  cysteine rich tail 1
  derlin 2
  F-box protein 45
  hes related family bHLH transcription factor with YRPW motif 2
  keratin associated protein 1-1
  keratin associated protein 11-1
  keratin associated protein 3-1
  keratin associated protein 4-4
  keratin associated protein 6-1
  keratin associated protein 6-2
  keratin associated protein 8-1
  SIN3 transcription regulator family member A
  synoviolin 1

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