KAT6B, lysine acetyltransferase 6B

KAT6B, lysine acetyltransferase 6B

• The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

• Gene Synonyms (histone acetyltransferase KAT6B, K(lysine) acetyltransferase 6B, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, MOZ-related factor, MYST histone acetyltransferase (monocytic leukemia) 4, MYST-4, histone acetyltransferase MORF, histone acetyltransferase MOZ2, histone acetyltransferase MYST4, monocytic leukemia zinc finger protein-related factor, GTPTS, MORF, MOZ2, MYST4, ZC2HC6B, qkf, querkopf,)
• NCBI Gene ID: 23522
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WYB5
  UNIPROT ID#>>B2RWN8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine acetyltransferase 6B interacts with:

• inhibitor of growth family member 5
  MYST/Esa1 associated factor 6
  shugoshin 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.