CLCF1, cardiotrophin like cytokine factor 1

CLCF1, cardiotrophin like cytokine factor 1

• This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

• Gene Synonyms (cardiotrophin-like cytokine factor 1, B-cell stimulatory factor 3, B-cell-stimulating factor 3, CRLF1 associated cytokine-like factor 1, neurotrophin-1/B-cell stimulating factor-3, novel neurotrophin-1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6,)
• NCBI Gene ID: 23529
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UBD9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cardiotrophin like cytokine factor 1 interacts with:

• agrin
  cardiotrophin like cytokine factor 1

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