BACE2, beta-secretase 2

BACE2, beta-secretase 2

• This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (beta-secretase 2, 56 kDa aspartic-like protease, Down syndrome region aspartic protease, SLCO3A1/BACE2 fusion, aspartyl protease 1, beta-site APP-cleaving enzyme 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme 2, memapsin-1, membrane-associated aspartic protease 1, theta-secretase, transmembrane aspartic proteinase Asp1, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP,)
• NCBI Gene ID: 25825
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9Y5Z0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

beta-secretase 2 interacts with:

• beta-secretase 2
  C-type lectin domain family 2 member D
  golgi associated, gamma adaptin ear containing, ARF binding protein 1
  interferon epsilon
  metallophosphoesterase 1
  tectonic family member 2
  transmembrane protein 30A
  transmembrane serine protease 11B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.