ARHGEF26, Rho guanine nucleotide exchange factor 26

ARHGEF26, Rho guanine nucleotide exchange factor 26

• This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (rho guanine nucleotide exchange factor 26, Rho guanine nucleotide exchange factor (GEF) 26, SH3 domain-containing guanine exchange factor, Src homology 3 domain-containing guanine nucleotide exchange factor, testicular tissue protein Li 171, CSGEF, HMFN1864, SGEF,)
• NCBI Gene ID: 26084
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJU4
  UNIPROT ID#>>B3KXG0
  UNIPROT ID#>>Q96DR7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 26 interacts with:

• alanyl-tRNA synthetase 2, mitochondrial
  aspartyl-tRNA synthetase 2, mitochondrial
  DDB1 and CUL4 associated factor 8
  lin-7 homolog C, crumbs cell polarity complex component
  pyruvate dehydrogenase phosphatase regulatory subunit

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.