FBXW2, F-box and WD repeat domain containing 2

FBXW2, F-box and WD repeat domain containing 2

• F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]

• Gene Synonyms (F-box/WD repeat-containing protein 2, F-box and WD-40 domain protein 2, F-box and WD-40 domain-containing protein 2, FBW2, Fwd2, Md6,)
• NCBI Gene ID: 26190
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKT8
  UNIPROT ID#>>B4DT60
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

F-box and WD repeat domain containing 2 interacts with:

• clavesin 2
  F-box and WD repeat domain containing 7
  F-box and WD repeat domain containing 8
  F-box protein 17
  F-box protein 6
  SPANX family member N3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.