HSPB8, heat shock protein family B (small) member 8

HSPB8, heat shock protein family B (small) member 8

• The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

• Gene Synonyms (heat shock protein beta-8, E2-induced gene 1 protein, alpha-crystallin C chain, heat shock 22kDa protein 8, heat shock 27kDa protein 8, protein kinase H11, small stress protein-like protein HSP22, CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22,)
• NCBI Gene ID: 26353
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJY1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heat shock protein family B (small) member 8 interacts with:

• acyl-CoA dehydrogenase family member 11
  ankyrin repeat and SOCS box containing 4
  ataxin 7 like 2
  C2 calcium dependent domain containing 6
  cytokine induced apoptosis inhibitor 1
  family with sequence similarity 214 member B
  family with sequence similarity 83 member H
  glutamine rich 1
  heat shock protein family B (small) member 6
  heat shock protein family B (small) member 7
  heat shock protein family B (small) member 8
  LON peptidase N-terminal domain and ring finger 2
  mitotic spindle positioning
  nudix hydrolase 12
  potassium channel tetramerization domain containing 13
  SET domain containing 2, histone lysine methyltransferase
  SMC hinge domain containing 1
  suppressor of cytokine signaling 7
  trafficking protein particle complex 6A
  tubulin tyrosine ligase-like family, member 12
  WD repeat domain 20
  zinc finger protein 92

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.