ITGB1BP2, integrin subunit beta 1 binding protein 2

ITGB1BP2, integrin subunit beta 1 binding protein 2

• This gene encodes a protein with two cysteine and histidine-rich (CHORD) domains, PXXP motifs, YXXI/P motifs, putative SH2 and SH3 domain binding motifs, and an acidic region at the C-terminus that can bind calcium. Two hybrid analysis showed that this protein interacts with the cytoplasmic domain of the beta 1 integrin subunit and is thought to act as a chaperone protein. Studies in the mouse ortholog of this gene indicate that absence of this gene in mouse results in failed cardiac hypertrophy in response to mechanical stress. Alternative splicing results in multiple transcript variants encoding different isoforms, including an isoform that lacks several domains, including one of the CHORD domains. [provided by RefSeq, May 2017]

• Gene Synonyms (integrin beta-1-binding protein 2, integrin beta 1 binding protein (melusin) 2, CHORDC3, ITGB1BP, MELUSIN, MSTP015,)
• NCBI Gene ID: 26548
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UKP3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit beta 1 binding protein 2 interacts with:

• exportin 5
  programmed cell death 2 like

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.