USP21, ubiquitin specific peptidase 21

USP21, ubiquitin specific peptidase 21

• This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

• Gene Synonyms (USP16, USP23, ubiquitin carboxyl-terminal hydrolase 21, NEDD8-specific protease, deubiquitinating enzyme 21, ubiquitin specific protease 21, ubiquitin thioesterase 21, ubiquitin thiolesterase 21, ubiquitin-specific processing protease 21, ubiquitin-specific protease 16,)
• NCBI Gene ID: 27005
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UK80
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 21 interacts with:

• ADAMTS like 4
  ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  BEN domain containing 3
  deltex E3 ubiquitin ligase 3
  DENN domain containing 1A
  DENN domain containing 4C
  DEP domain containing 1B
  DExH-box helicase 58
  EGF containing fibulin extracellular matrix protein 2
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  family with sequence similarity 53 member C
  goosecoid homeobox
  GRB10 interacting GYF protein 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  interferon induced with helicase C domain 1
  interleukin 33
  keratin 40
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat and sterile alpha motif containing 1
  LIM domain and actin binding 1
  MAPK associated protein 1
  microtubule affinity regulating kinase 4
  mitogen-activated protein kinase kinase kinase 21
  NAD kinase
  Nanog homeobox
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  polycomb group ring finger 6
  potassium channel tetramerization domain containing 11
  potassium channel tetramerization domain containing 3
  potassium channel tetramerization domain containing 6
  potassium channel tetramerization domain containing 9
  protein phosphatase 6 regulatory subunit 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  RAB3A interacting protein
  ring finger protein 185
  RNA binding motif protein 45
  serine and arginine rich splicing factor 12
  SMC5-SMC6 complex localization factor 1
  SUMO peptidase family member, NEDD8 specific
  synapse defective Rho GTPase homolog 1
  tripartite motif containing 5
  tripartite motif containing 54
  tripartite motif containing 63
  tripartite motif containing 8
  tripartite motif containing 9
  ubiquitin conjugating enzyme E2 S
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 48
  ubiquitin specific peptidase 51
  UPF3B regulator of nonsense mediated mRNA decay
  YOD1 deubiquitinase
  zinc finger and BTB domain containing 21
  zinc finger protein 350
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.