GNMT, glycine N-methyltransferase

GNMT, glycine N-methyltransferase

• The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]

• Gene Synonyms (glycine N-methyltransferase, epididymis secretory sperm binding protein Li 182mP, HEL-S-182mP,)
• NCBI Gene ID: 27232
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5F2
  UNIPROT ID#>>Q14749
  UNIPROT ID#>>V9HW60
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycine N-methyltransferase interacts with:

• ADAMTS like 4
  coiled-coil domain containing 153
  G antigen 2A
  gamma-aminobutyric acid type A receptor subunit theta
  glycine N-methyltransferase
  histone deacetylase 7
  keratin associated protein 10-3
  keratin associated protein 4-2
  NGG1 interacting factor 3 like 1
  notch 2 N-terminal like A
  N-terminal glutamine amidase 1
  nudix hydrolase 18
  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
  pleckstrin homology and FYVE domain containing 2
  TERF2 interacting protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.