TNFRSF21, TNF receptor superfamily member 21

TNFRSF21, TNF receptor superfamily member 21

• This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 21, TNFR-related death receptor 6, death receptor 6, BM-018, CD358, DR6,)
• NCBI Gene ID: 27242
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75509
  UNIPROT ID#>>A0A024RD71
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 21 interacts with:

• nuclear receptor binding SET domain protein 1

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