CAVIN1, caveolae associated protein 1

CAVIN1, caveolae associated protein 1

• This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

• Gene Synonyms (caveolae-associated protein 1, RNA polymerase I and transcript release factor, TTF-I interacting peptide 12, congenital generalized lipodystrophy 4, polymerase I and transcript release factor, CAVIN, CGL4, FKSG13, PTRF, cavin-1,)
• NCBI Gene ID: 284119
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6NZI2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

caveolae associated protein 1 interacts with:

• caveolae associated protein 1
  pleckstrin homology like domain family B member 3
  SPANX family member N2
  tripartite motif containing 72

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.