SETD2, SET domain containing 2, histone lysine methyltransferase

SETD2, SET domain containing 2, histone lysine methyltransferase

• Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]

• Gene Synonyms (histone-lysine N-methyltransferase SETD2, SET domain containing 2, huntingtin interacting protein 1, huntingtin yeast partner B, huntingtin-interacting protein B, lysine N-methyltransferase 3A, protein-lysine N-methyltransferase SETD2, HBP231, HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, SET2, p231HBP,)
• NCBI Gene ID: 29072
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BYW2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SET domain containing 2, histone lysine methyltransferase interacts with:

• chromobox 8
  heterogeneous nuclear ribonucleoprotein L like
  interacts with SUPT6H, CTD assembly factor 1
  LUC7 like
  nuclear RNA export factor 2
  polycomb group ring finger 1
  round spermatid basic protein 1
  scavenger receptor class A member 3
  SET domain containing 2, histone lysine methyltransferase
  suppressor of glucose, autophagy associated 1
  tubulin tyrosine ligase-like family, member 7

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.