IRGM, immunity related GTPase M

IRGM, immunity related GTPase M

• This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]

• Gene Synonyms (IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase family M protein, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47-like protein, immunity-related GTPase family, M1, interferon-inducible protein 1,)
• NCBI Gene ID: 345611
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A1A4Y4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

immunity related GTPase M interacts with:

• immunity related GTPase M
  microtubule associated protein 1 light chain 3 gamma

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.