RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B

RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B

• This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

• Gene Synonyms (ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2 homolog, p53-inducible ribonucleotide reductase small subunit 2 short form beta, p53-inducible ribonucleotide reductase small subunit 2-like protein, ribonucleotide reductase M2 B (TP53 inducible), MTDPS8A, MTDPS8B, P53R2,)
• NCBI Gene ID: 50484
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7LG56
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ribonucleotide reductase regulatory TP53 inducible subunit M2B interacts with:

• activation induced cytidine deaminase
  fizzy and cell division cycle 20 related 1
  ribonucleotide reductase regulatory TP53 inducible subunit M2B

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