ARHGEF3, Rho guanine nucleotide exchange factor 3

ARHGEF3, Rho guanine nucleotide exchange factor 3

• Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (rho guanine nucleotide exchange factor 3, 59.8 kDA protein, Rho guanine nucleotide exchange factor (GEF) 3, RhoGEF protein, exchange factor found in platelets and leukemic and neuronal tissues, XPLN, GEF3, STA3, XPLN,)
• NCBI Gene ID: 50650
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NR81
  UNIPROT ID#>>B7Z6B2
  UNIPROT ID#>>E9PG37
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 3 interacts with:

• centrosomal protein 70
  PBX homeobox 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.