ZBTB7B, zinc finger and BTB domain containing 7B

ZBTB7B, zinc finger and BTB domain containing 7B

• This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

• Gene Synonyms (zinc finger and BTB domain-containing protein 7B, T-helper-inducing POZ/Krueppel-like factor, krueppel-related zinc finger protein cKrox, zinc finger and BTB domain containing 15, zinc finger protein 67 homolog, zinc finger protein 857B, zinc finger protein Th-POK, CKROX, THPOK, ZBTB15, ZFP-67, ZFP67, ZNF857B, c-KROX, hcKROX,)
• NCBI Gene ID: 51043
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15156
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

zinc finger and BTB domain containing 7B interacts with:

• agrin
  BCL6B transcription repressor
  cereblon
  cyclin L2
  family with sequence similarity 90 member A1
  histone deacetylase 10
  IMP U3 small nucleolar ribonucleoprotein 4
  prolyl 4-hydroxylase subunit alpha 3
  ribosomal protein L35
  synaptotagmin like 4
  upstream binding transcription factor like 1
  zinc finger and BTB domain containing 42
  zinc finger and BTB domain containing 7A
  zinc finger and BTB domain containing 7B
  zinc finger and SCAN domain containing 5B

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.