TFB1M, transcription factor B1, mitochondrial

TFB1M, transcription factor B1, mitochondrial

• The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).[provided by RefSeq, Aug 2010]

• Gene Synonyms (dimethyladenosine transferase 1, mitochondrial, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1, h-mtTFB1, hTFB1M, homolog of yeast mitochondrial transcription factor B, mitochondrial 12S rRNA dimethylase 1, mitochondrial dimethyladenosine transferase 1, CGI-75, CGI75, mtTFB, mtTFB1,)
• NCBI Gene ID: 51106
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WVM0
  UNIPROT ID#>>E5KTM5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

transcription factor B1, mitochondrial interacts with:

• cullin associated and neddylation dissociated 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  MUS81 structure-specific endonuclease subunit
  receptor interacting serine/threonine kinase 4
  ribosomal protein L35
  RIO kinase 1
  signal recognition particle 72
  transcription factor B1, mitochondrial
  ybeY metalloendoribonuclease

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.