ANGPTL4, angiopoietin like 4

ANGPTL4, angiopoietin like 4

• This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

• Gene Synonyms (angiopoietin-related protein 4, PPARG angiopoietin related protein, fasting-induced adipose factor, hepatic angiopoietin-related protein, hepatic fibrinogen/angiopoietin-related protein, peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158,)
• NCBI Gene ID: 51129
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BY76
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

angiopoietin like 4 interacts with:

• aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
  F-box and WD repeat domain containing 7
  peptidase M20 domain containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.