TRMT6, tRNA methyltransferase 6

TRMT6, tRNA methyltransferase 6

• This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6, tRNA methyltransferase 6 homolog, tRNA(m1A58)MTase subunit TRM6, CGI-09, GCD10, Gcd10p,)
• NCBI Gene ID: 51605
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UJA5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tRNA methyltransferase 6 interacts with:

• COBW domain containing 1
  cullin associated and neddylation dissociated 1
  decapping mRNA 1A
  dihydrouridine synthase 3 like
  DLG associated protein 4
  DNA damage inducible 1 homolog 2
  DnaJ heat shock protein family (Hsp40) member C17
  kelch like family member 22
  leucine rich repeat containing 8 VRAC subunit E
  Nanog homeobox
  neuropilin and tolloid like 2
  nicastrin
  pseudouridine synthase 1
  ring finger protein 123
  shootin 1
  talin 2
  tRNA methyltransferase 61A
  ubiquitin specific peptidase 43
  VPS35 retromer complex component

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.