ASB2, ankyrin repeat and SOCS box containing 2

ASB2, ankyrin repeat and SOCS box containing 2

• This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (ankyrin repeat and SOCS box protein 2, ankyrin repeat and SOCS box-containing protein 2a, ASB-2,)
• NCBI Gene ID: 51676
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96Q27
  UNIPROT ID#>>A0A024R6E7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ankyrin repeat and SOCS box containing 2 interacts with:

• ankyrin repeat and SOCS box containing 2
  cullin associated and neddylation dissociated 1
  defective in cullin neddylation 1 domain containing 3
  spindlin interactor and repressor of chromatin binding

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.