RBFOX1, RNA binding fox-1 homolog 1

RBFOX1, RNA binding fox-1 homolog 1

• The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (RNA binding protein fox-1 homolog 1, RNA binding protein, fox-1 homolog 1, ataxin 2-binding protein 1, fox-1 homolog A, fox-1-like RNA-binding protein 1, hexaribonucleotide binding protein 1 isoform alpha, hexaribonucleotide binding protein 1 isoform beta, hexaribonucleotide-binding protein 1, 2BP1, A2BP1, FOX-1, FOX1, HRNBP1,)
• NCBI Gene ID: 54715
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q59HD3
  UNIPROT ID#>>X5DP44
  UNIPROT ID#>>B7Z1U7
  UNIPROT ID#>>Q9NWB1
  UNIPROT ID#>>X5DNY3
  UNIPROT ID#>>X5D7T5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA binding fox-1 homolog 1 interacts with:

• ALG13 UDP-N-acetylglucosaminyltransferase subunit
  ataxin 1 like
  calpain small subunit 2
  chromosome 1 open reading frame 94
  coordinator of PRMT5 and differentiation stimulator
  DMRT like family B with proline rich C-terminal 1
  GATA zinc finger domain containing 1
  heat shock transcription factor family, X-linked 1
  heat shock transcription factor Y-linked 1
  leucine zipper tumor suppressor 2
  PHD finger protein 12
  poly(rC) binding protein 4
  proline rich 20A
  prolyl 4-hydroxylase subunit alpha 3
  Rhox homeobox family member 2
  ring finger protein 25
  RIO kinase 1
  RNA binding fox-1 homolog 1
  RNA binding motif protein 24
  RNA binding protein, mRNA processing factor 2
  serpin family A member 12
  short chain dehydrogenase/reductase family 9C member 7
  spermatid perinuclear RNA binding protein
  testis expressed 37

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.