ARFGAP1, ADP ribosylation factor GTPase activating protein 1

ARFGAP1, ADP ribosylation factor GTPase activating protein 1

• The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Gene Synonyms (ARF1GAP, HRIHFB2281, ADP-ribosylation factor GTPase-activating protein 1, ARF1-directed GTPase-activating protein,)
• NCBI Gene ID: 55738
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N6T3
  UNIPROT ID#>>Q53F62
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ADP ribosylation factor GTPase activating protein 1 interacts with:

• ADP ribosylation factor GTPase activating protein 2
  ankyrin repeat and SOCS box containing 10
  DDB1 and CUL4 associated factor 15
  disco interacting protein 2 homolog B
  keratin associated protein 10-9
  keratin associated protein 3-2
  keratin associated protein 9-2
  leucine rich repeat kinase 2
  microtubule associated protein 1 light chain 3 beta
  POTE ankyrin domain family member F
  retinol dehydrogenase 12
  RIC8 guanine nucleotide exchange factor A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.