FANCM, FA complementation group M

FANCM, FA complementation group M

• The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

• Gene Synonyms (FAAP250, KIAA1596, POF15, SPGF28, Fanconi anemia group M protein, ATP-dependent RNA helicase FANCM, Fanconi anemia complementation group M, fanconi anemia-associated polypeptide of 250 kDa, protein Hef ortholog,)
• NCBI Gene ID: 57697
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IYD8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FA complementation group M interacts with:

• centromere protein S
  centromere protein X
  centrosomal protein 85-like
  essential meiotic structure-specific endonuclease subunit 2
  FA complementation group M
  FA core complex associated protein 100
  FA core complex associated protein 20
  FA core complex associated protein 24
  leucine rich repeat kinase 2
  PDX1 C-terminal inhibiting factor 1
  RecQ mediated genome instability 1
  RecQ mediated genome instability 2
  SAS-6 centriolar assembly protein
  UFM1 specific ligase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.