DENND1A, DENN domain containing 1A

DENND1A, DENN domain containing 1A

• Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]

• Gene Synonyms (FAM31A, KIAA1608, DENN domain-containing protein 1A, DENN/MADD domain containing 1A, connecdenn 1,)
• NCBI Gene ID: 57706
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9HCG4
  UNIPROT ID#>>Q8TEH3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DENN domain containing 1A interacts with:

• ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  atlastin GTPase 2
  enhancer of mRNA decapping 3
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  GRB10 interacting GYF protein 1
  lipin 3
  MAPK associated protein 1
  mitogen-activated protein kinase kinase kinase 21
  NAD kinase
  neuron navigator 1
  oxysterol binding protein like 6
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  Sec24 related gene family, member C (S. cerevisiae)
  serine and arginine rich splicing factor 12
  SH3 domain containing ring finger 3
  StAR related lipid transfer domain containing 13
  synapse defective Rho GTPase homolog 1

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