ARHGAP22, Rho GTPase activating protein 22

ARHGAP22, Rho GTPase activating protein 22

• This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (rho GTPase-activating protein 22, rho-type GTPase-activating protein 22, RhoGAP2, RhoGap22,)
• NCBI Gene ID: 58504
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z5H3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho GTPase activating protein 22 interacts with:

• ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  dedicator of cytokinesis 11
  ERI1 exoribonuclease family member 3
  iron-sulfur cluster assembly factor IBA57
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  phospholipase C delta 3
  programmed cell death 2 like

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.