SELPLG, selectin P ligand

SELPLG, selectin P ligand

• This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

• Gene Synonyms (P-selectin glycoprotein ligand 1, cutaneous lymphocyte-associated associated antigen, CD162, CLA, PSGL-1, PSGL1,)
• NCBI Gene ID: 6404
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14242
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

selectin P ligand interacts with:

• beta-secretase 1
  polypeptide N-acetylgalactosaminyltransferase 4
  selectin P ligand
  solute carrier family 13 member 1
  spleen associated tyrosine kinase
  TNFAIP3 interacting protein 1
  tyrosylprotein sulfotransferase 1
  tyrosylprotein sulfotransferase 2

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