SLC39A8, solute carrier family 39 member 8

SLC39A8, solute carrier family 39 member 8

• This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

• Gene Synonyms (metal cation symporter ZIP8, BCG induced integral membrane protein BIGM103, BCG-induced integral membrane protein in monocyte clone 103 protein, LIV-1 subfamily of ZIP zinc transporter 6, ZIP-8, Zrt- and Irt-like protein 8, solute carrier family 39 (metal ion transporter), member 8, zinc transporter ZIP8, BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8,)
• NCBI Gene ID: 64116
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9C0K1
  UNIPROT ID#>>A0A024RDG0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

solute carrier family 39 member 8 interacts with:

• LEM domain nuclear envelope protein 2
  regulator of microtubule dynamics 2
  signal peptide peptidase like 3
  sphingosine-1-phosphate phosphatase 1
  transmembrane protein 179B
  transmembrane protein with metallophosphoesterase domain

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.