VPS33A, VPS33A core subunit of CORVET and HOPS complexes

VPS33A, VPS33A core subunit of CORVET and HOPS complexes

• This gene encodes a tethering protein and a core subunit of the homotypic fusion and protein sorting (HOPS) complex. The HOPS complex and a second endosomal tethering complex called the class C core vacuole/endosome tethering (CORVET) complex, perform diverse functions in endocytosis including membrane tethering, RabGTPase interaction, activation and proofreading of synaptic-soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) assembly to drive membrane fusion, and endosome-to-cytoskeleton attachment. The HOPS complex controls endosome maturation as well as endosome traffic to the lysosome. This complex is essential for vacuolar fusion and is required for adaptor protein complex 3-dependent transport from the golgi to the vacuole. The encoded protein belongs to the Sec1/Munc18 (SM) family of SNARE-mediated membrane fusion regulators. Naturally occurring mutations in this gene are associated with a novel mucopolysaccharidosis-like disease. [provided by RefSeq, Apr 2017]

• Gene Synonyms (vacuolar protein sorting-associated protein 33A, VPS33A, CORVET/HOPS core subunit, vacuolar protein sorting 33 homolog A, vacuolar protein sorting 33A, MPSPS,)
• NCBI Gene ID: 65082
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96AX1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

VPS33A core subunit of CORVET and HOPS complexes interacts with:

• MON1 homolog A, secretory trafficking associated
  splicing regulatory glutamic acid and lysine rich protein 1
  tektin 4
  VPS41 HOPS complex subunit
  zinc finger containing ubiquitin peptidase 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.