CXCR4, C-X-C motif chemokine receptor 4

CXCR4, C-X-C motif chemokine receptor 4

• This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C-X-C chemokine receptor type 4, CD184 antigen, LPS-associated protein 3, SDF-1 receptor, chemokine (C-X-C motif) receptor 4, chemokine receptor, fusin, leukocyte-derived seven transmembrane domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, neuropeptide Y3 receptor, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, stromal cell-derived factor 1 receptor, CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS,)
• NCBI Gene ID: 7852
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P61073
  UNIPROT ID#>>A0A0U3FJG0
  UNIPROT ID#>>A0A0U3GXA9
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-X-C motif chemokine receptor 4 interacts with:

• ATPase cation transporting 13A2
  beta-1,4-glucuronyltransferase 1
  coiled-coil domain containing 107
  C-X-C motif chemokine receptor 4
  G protein subunit alpha 13
  glucosaminyl (N-acetyl) transferase 3, mucin type
  golgi transport 1B
  inositol-pentakisphosphate 2-kinase
  IQ motif containing GTPase activating protein 1
  itchy E3 ubiquitin protein ligase
  MTSS I-BAR domain containing 1
  PC4 and SFRS1 interacting protein 1
  potassium channel, subfamily K, member 1
  signal transducing adaptor molecule
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 3
  transmembrane protein 171
  transmembrane protein 63B
  ubiquitin specific peptidase 14
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.