LIN28A, lin-28 homolog A

LIN28A, lin-28 homolog A

• This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

• Gene Synonyms (protein lin-28 homolog A, RNA-binding protein LIN-28, zinc finger CCHC domain-containing protein 1, zinc finger, CCHC domain containing 1, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A,)
• NCBI Gene ID: 79727
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H9Z2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lin-28 homolog A interacts with:

• DEAH-box helicase 36
  DExH-box helicase 57
  DOT1 like histone lysine methyltransferase
  GADD45G interacting protein 1
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein U like 2
  La ribonucleoprotein 4
  LTV1 ribosome biogenesis factor
  nitric oxide associated 1
  splicing regulatory glutamic acid and lysine rich protein 1
  trimethylguanosine synthase 1
  tripartite motif containing 71

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.